AL-LAD Blotter Paper

It gained recognition after Alexander Shulgin described the substance in the book TIHKAL, although David Nichols and Albert Hofmann described AL-LAD 12 years before that in an article.

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Because it is not an alkyl analogue it bypasses UK drug analogue laws.

Lysergic N,N-diethylamide (LSD) is perhaps one of the most intriguing psychoactive substances known and numerous analogs have been explored to a varying extent in previous decades.

In 2013, N⁶-allyl-6-norlysergic acid diethylamide (AL-LAD) and (2’S,4’S)-lysergic acid 2,4-dimethylazetidide (LSZ). Have appeared on the ‘research chemicals’ / new psychoactive substances (NPS) market in both powdered and blotter form.

This study reports the analytical characterization of powdered AL-LAD and LSZ tartrate samples and their semi-quantitative determination on blotter paper. Included in this study was the use of nuclear magnetic resonance spectroscopy, gas chromatography mass spectrometry (MS). Low and high-resolution electrospray MS(/MS), high performance liquid chromatography diode array detection and GC solid-state infrared analysis.

One feature shared by serotonergic psychedelics, such as LSD, is the ability to mediate behavioral responses via activation of 5-HT_2A receptors. Both AL-LAD and LSZ displayed LSD-like responses in male C57BL/6J mice when employing the head-twitch response (HTR) assay. AL-LAD and LSZ produced nearly identical inverted-U-shaped dose-dependent effects, with the maximal responses occurring at 200 µg/kg.

Analysis of the dose-responses by nonlinear regression confirmed that LSZ (ED₅₀ = 114.2 nmol/kg) was equipotent. To LSD (ED₅₀ = 132.8 nmol/kg) in mice, whereas AL-LAD was slightly less potent (ED₅₀ = 174.9 nmol/kg).